Barbiturate- and Thiobarbituarte-Based s-Triazine Hydrazone Derivatives with Promising Antiproliferative Activities
نویسندگان
چکیده
منابع مشابه
Biological activities of hydrazone derivatives.
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and antischistosomiasis activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Th...
متن کاملSynthesis, crystal structures and spectroscopic properties of triazine-based hydrazone derivatives; a comparative experimental-theoretical study.
We report here a comparative theoretical and experimental study of four triazine-based hydrazone derivatives. The hydrazones are synthesized by a three step process from commercially available benzil and thiosemicarbazide. The structures of all compounds were determined by using the UV-Vis., FT-IR, NMR (1H and 13C) spectroscopic techniques and finally confirmed unequivocally by single crystal X...
متن کاملNitrogen-14 NQR in s-Triazine Derivatives*
Within a study of the temperature dependence of NQR frequencies in some s-triazine derivatives [1], resonance frequencies at 4.2 K were determined in melamine, cyanuric acid, and cyanuric chloride. New lines, which were not reported so far, were detected in two of these compounds. In melamine, nine more lines were found as already described in [4], In cyanuric chloride, two more lines were foun...
متن کاملSynthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives
Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C₉H16C=O, into a number of derivatives including hydrazones, C₉H16C=N-NHAr 3, imines, C₉H16C=N-R 7, and the key intermediate nitroimine, C₉H16C=N-NO₂ 6. Reactions of nitroamine 6 with nucleophiles by classical methods provided the desired compounds in a range of yields...
متن کاملSynthesis, In-silico Studies, of New Substituted Pyrazolone Based Hydrazone Derivatives and Their Biological Activities
In silico studies have been helpful in identifying the potential lead molecules with reduced cost. The title compounds were synthesized successfully by the reported method and the structures were confirmed on the basis of results of different spectral data. The in silico studies were carried out to find the possibility of the proposed activity using different software’s. Molinspiration, Osiris ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Omega
سال: 2020
ISSN: 2470-1343,2470-1343
DOI: 10.1021/acsomega.0c00468